Perpherally Restricted Diphenyl Purine Dervatives
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چکیده
Fulp et al., “Diphenyl Purine Derivatives as Peripherally Selective Cannabinoid Receptor 1 Antagonists,” Journal of Medicinal Chem istry, 2012, pp. 10022-10032, vol. 55, No. 2. Griffith et al., “Discovery of 1-9-(4-Chlorophenyl)-8-(2chlorophenyl)-9H-purin-6-yl)-4-ethylaminopiperidine-4-carbox ylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist.” J. Med Chem. 2009, vol. 52, pp. 234-237. Ragan et al., “Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB Antagonist for the Treatment of Obesity.” Organic Process Research & Development, 2009, vol. 13, pp. 186-197.
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